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In the thirties, elixir sulfanilamide, an antibiotic mixed into a toxic solvent, gave patients intense pain, kidney failure, and neurological problems

Hair loss sometimes occurs 3-6 months into therapy

Consequently, researchers designing head-to-head comparison protocols between the two formulations source both from one supplier with batch-matched documentation and avoid the inter-vendor variability that would otherwise confound their results

However, if split dosing improves your adherence and reduces side effects, the practical benefit may outweigh theoretical pharmacokinetic concerns

This means HCG is only available as a commercial prescription, and patients report that this route often costs more